Details of Epigenetic Molecule(EM)
| General Information of EM (ID: EM11863) | |||||||
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| Official Symbol |
AK4
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| Official Full Name |
Adenylate Kinase 4
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| Synonym |
Adenylate Kinase 4;AK3L1;AK3;Adenylate Kinase 4, Mitochondrial;Adenylate Kinase 3-Like 1;Mitochondrial Adenylate Kinase-3;GTP:AMP Phosphotransferase AK4;ATP-AMP Transphosphorylase;Adenylate Kinase 3-Like
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| Molecule Type |
Protein coding
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| Position On Chromosome |
chr1(Start:65147342 - End:65232145)
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| Strand |
+
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| Uniprot Entry | |||||||
| ENSG ID | |||||||
| Disease Relevance (Click to Show/Hide) | |||||||
| 2C30: Melanoma of skin | Cutaneous Melanoma [Melanoma of skin] | ||||||
| Detailed Information |
Disease Link
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| 8A01: Choreiform disorders | Huntington's disease (HD) [Choreiform disorders] | ||||||
| Detailed Information |
Disease Link
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| 8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
| Detailed Information |
Disease Link
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| CB03: Idiopathic interstitial pneumonitis | Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis] | ||||||
| Detailed Information |
Disease Link
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| LD2C: Overgrowth syndromes | Sotos syndrome(SS) [Overgrowth syndromes] | ||||||
| Detailed Information |
Disease Link
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| SE30: Developmental delay disorder | CHARGE and Kabuki syndromes [Developmental delay disorder] | ||||||
| Detailed Information |
Disease Link
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| Metabolite(s) with this epigenetic modification | |||||||
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| Metabolite Name: Arachidonic acid | |||||||
| Detailed Information |
Meta Info
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[1] | |||||
| Description |
Arachidonic acid could induce AK3L1 gene hypermethylation in THP-1 cells.
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| References | |||||
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| 1 | Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597. | ||||
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