Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11855)
  Official Symbol
ADARB1
  Official Full Name
Adenosine Deaminase RNA Specific B1
  Synonym
DRADA2;ADAR2;RED1;DRABA2;Adenosine Deaminase, RNA-Specific, B1 (Homolog Of Rat RED1);Double-Stranded RNA-Specific Editase 1;RNA-Editing Enzyme 1
  Molecule Type
Protein coding
  Position On Chromosome
chr21(Start:45073853 - End:45226563)
  Strand
+
  Uniprot Entry
P78563 
  ENSG ID
ENSG00000197381 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2B: Syndromes with premature ageing appearance as a major feature Werner Syndrome [Syndromes with premature ageing appearance as a major feature]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce ADARB1 gene hypermethylation in THP-1 cells.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract J Clin Med. 2019 Jul 24;8(8):1090. doi: 10.3390/jcm8081090.

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