Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM11850)
  Official Symbol
ABI1
  Official Full Name
Abl Interactor 1
  Synonym
Abl Interactor 1;E3B1;SSH3BP1;ABI-1;Spectrin SH3 Domain-Binding Protein 1;Eps8 SH3 Domain-Binding Protein;Abl-Binding Protein 4;Abelson Interactor 1;Spectrin SH3 Domain Binding Protein 1;Abl-Interactor Protein 1 Long;Interactor Protein AblBP4;Nap1 Binding Protein;Eps8-Binding Protein;Nap1-Binding Protein;Abl-Interactor 1;ABLBP4;NAP1BP;SSH3BP;AblBP4;Nap1BP;Abi-1
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:26746593 - End:26861087)
  Strand
-
  Uniprot Entry
Q8IZP0 
  ENSG ID
ENSG00000136754 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid could induce ABI1 gene hypermethylation in THP-1 cells.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract J Clin Med. 2019 Jul 24;8(8):1090. doi: 10.3390/jcm8081090.

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