Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10579)
  Official Symbol
GRB2
  Official Full Name
growth factor receptor bound protein 2
  Synonym
NCKAP2
  Molecule Type
Protein coding
  Position On Chromosome
chr17(Start:75318076 - End:75405709)
  Strand
-
  Uniprot Entry
P62993 
  ENSG ID
ENSG00000177885 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate GRB2 CpG site in breast cancer cells.
  Metabolite Name: Resveratrol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Resveratrol could change tumor suppressor gene GRB2 from hypomethylated to hypermethylated status in MDA-MB-231 breast cancer cells treated with resveratrol (100 M) at 48 h.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Methylation Landscape of Human Breast Cancer Cells in Response to Dietary Compound Resveratrol. PLoS One. 2016 Jun 29;11(6):e0157866. doi: 10.1371/journal.pone.0157866. eCollection 2016.

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