Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10067)
Official Symbol		KDM6B
Official Full Name		Lysine demethylase 6B
Synonym		JMJD3;NEDCFSA
Molecule Type		Protein coding
Position On Chromosome		chr17(Start:7834217 - End:7854796)
Strand		+
Uniprot Entry		O15054
ENSG ID		ENSG00000132510

Metabolite(s) with this epigenetic modification
Metabolite Name: Lipopolysaccharide
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Lipopolysaccharide (LPS) could downregulate JMJD3 (p < 0.01) gene expression in HaCaT cells.

References
1	Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
2	Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

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