Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM01004)
  Official Symbol
URB2
  Official Full Name
URB2 ribosome biogenesis homolog
  Synonym
KIAA0133;NET10;NPA2
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:229626247 - End:229660200)
  Strand
+
  Uniprot Entry
Q14146 
  ENSG ID
ENSG00000135763 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
            Detailed Information Disease Link click to show the detail information of this Disease
         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
            Detailed Information Disease Link click to show the detail information of this Disease
         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
            Detailed Information Disease Link click to show the detail information of this Disease
         5B81: Obesity Obesity [Obesity]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A20: Schizophrenia Schizophrenia [Schizophrenia]
            Detailed Information Disease Link click to show the detail information of this Disease
         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
            Detailed Information Disease Link click to show the detail information of this Disease
         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
            Detailed Information Disease Link click to show the detail information of this Disease
         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
            Detailed Information Disease Link click to show the detail information of this Disease
         GA10: Endometriosis Endometriosis [Endometriosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2F: Syndromes with multiple structural anomalies, without predominant body system involvement Silver russell syndrome [Syndromes with multiple structural anomalies, without predominant body system involvement]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SD86: Dementia disorder Dementia [Dementia disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH1E13: Germinoma Germinoma [Germinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH3DV3: Adenoma Adenoma [Adenoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4S92: Leukaemia Leukemia [Leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4V32: Ductal carcinoma in situ Ductal carcinoma in situ (DCIS) [Ductal carcinoma in situ]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate URB2 CpG site in breast cancer cells.

Protein(s) with this epigenetic modification
  Protein Name: DNA cytosine methyltransferase
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
DNA cytosine methyltransferase(MTases) could be associated with the decrease GATC-specific methylation in important cancer-specific genes, such as URB2.
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [4]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host URB2 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells Epigenetics. 2015;10(4):303-18. doi: 10.1080/15592294.2015.1020000. Epub 2015 Feb 19.
4 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.