Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00827)
  Official Symbol
RGS1
  Official Full Name
regulator of G protein signaling 1
  Synonym
1R20;BL34;IER1;IR20
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:192575763 - End:192580024)
  Strand
+
  Uniprot Entry
A0A024R945 
  ENSG ID
ENSG00000090104 
  Dnmivd Disease
KIRC 
    Disease Relevance (Click to Show/Hide)
         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A00: Primary neoplasms of brain Oligodendroglial tumors [Primary neoplasms of brain]
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         2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C73: Malignant neoplasms of ovary Ovarian serous adenocarcinoma (OSA) [Malignant neoplasms of ovary]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         5A61: Hypofunction or certain specified disorders of pituitary gland Congenital hypopituitarism [Hypofunction or certain specified disorders of pituitary gland]
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         5B81: Obesity Obesity [Obesity]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LD2B: Syndromes with premature ageing appearance as a major feature Premature aging diseases [Syndromes with premature ageing appearance as a major feature]
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         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
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         MG30: Chronic pain Fibromyalgia [Chronic pain]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1ND9: Papillary carcinoma of thyroid Papillary thyroid carcinoma [Papillary carcinoma of thyroid]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH74S1: Adenocarcinoma Small bowel adenocarcinoma [Adenocarcinoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8D74: Carcinomatosis Cancer [Carcinomatosis]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH98Z3: Schwannoma Schwannoma [Schwannoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN3DY: Helicobacter pylori Helicobacter pylori infection [Helicobacter pylori]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Docosahexaenoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Docosahexaenoic acid could altere the DNA methylation of RGS1 CpG loci.(cg26292058)

Protein(s) with this epigenetic modification
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host RGS1 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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