Details of Epigenetic Molecule(EM)
| General Information of EM (ID: EM00034) | |||||||
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| Official Symbol |
MMP2
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| Official Full Name |
matrix metallopeptidase 2
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| Synonym |
CLG4;CLG4A;TBE-1
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| Molecule Type |
Protein coding
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| Position On Chromosome |
chr16(Start:55389700 - End:55506691)
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| Strand |
+
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| Uniprot Entry | |||||||
| ENSG ID | |||||||
| Dnmivd Disease | |||||||
| Disease Relevance (Click to Show/Hide) | |||||||
| 1B10: Tuberculosis of the respiratory system | Tuberculosis (TB) [Tuberculosis of the respiratory system] | ||||||
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| 2A00: Primary neoplasms of brain | Choroid plexus tumors [Primary neoplasms of brain] | ||||||
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| 2A01: Primary neoplasms of meninges | Meningioma [Primary neoplasms of meninges] | ||||||
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| 2B50: Chondrosarcoma | Central chondrosarcoma [Chondrosarcoma] | ||||||
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| 2B6B: Malignant neoplasms of nasopharynx | Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx] | ||||||
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| 2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx | Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx] | ||||||
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| 2B70: Malignant neoplasms of oesophagus | Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus] | ||||||
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| 2B92: Malignant neoplasms of rectum | Rectal cancer [Malignant neoplasms of rectum] | ||||||
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| 2C10: Malignant neoplasm of pancreas | Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas] | ||||||
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| 2C25: Malignant neoplasms of bronchus or lung | Lung adenocarcinoma [Malignant neoplasms of bronchus or lung] | ||||||
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| 2C60: Carcinoma of breast | Breast cancer [Carcinoma of breast] | ||||||
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| 2C73: Malignant neoplasms of ovary | Ovarian carcinoma (OVCA) [Malignant neoplasms of ovary] | ||||||
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| 2C73: Malignant neoplasms of ovary | High grade serous ovarian cancer (HGSOC) [Malignant neoplasms of ovary] | ||||||
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| 2D10: Malignant neoplasms of thyroid gland | Thyroid tumors [Malignant neoplasms of thyroid gland] | ||||||
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| 4A40: Lupus erythematosus | Systemic lupus erythematosus (SLE) [Lupus erythematosus] | ||||||
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| 4A84: Anaphylaxis | Allergy [Anaphylaxis] | ||||||
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| 5A72: Hyperaldosteronism | Primary aldosteronism [Hyperaldosteronism] | ||||||
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| 6A02: Autism spectrum disorder | Autism [Autism spectrum disorder] | ||||||
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| 6A20: Schizophrenia | Schizophrenia [Schizophrenia] | ||||||
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| 6A7Z: Depressive disorders | Depression [Depressive disorders] | ||||||
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| 8A20: Alzheimer disease | Alzheimer's disease [Alzheimer disease] | ||||||
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| 8A40: Multiple sclerosis | Multiple sclerosis [Multiple sclerosis] | ||||||
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| 8E49: Postviral fatigue syndrome | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [Postviral fatigue syndrome] | ||||||
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| CA22: Chronic obstructive pulmonary disease | Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease] | ||||||
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| CA23: Asthma | Asthma [Asthma] | ||||||
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| CB03: Idiopathic interstitial pneumonitis | Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis] | ||||||
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| DB93: Hepatic fibrosis or cirrhosis | Cirrhotic [Hepatic fibrosis or cirrhosis] | ||||||
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| EE60: Keloid or hypertrophic scars | Keloid [Keloid or hypertrophic scars] | ||||||
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| FA0Z: Osteoarthritis | Osteoarthritis (OA) [Osteoarthritis] | ||||||
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| FA20: Rheumatoid arthritis | Rheumatoid arthritis [Rheumatoid arthritis] | ||||||
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| GA10: Endometriosis | Endometriosis [Endometriosis] | ||||||
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| JA24: Pre-eclampsia | Preeclampsia (PE) [Pre-eclampsia] | ||||||
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| LD2C: Overgrowth syndromes | Sotos syndrome(SS) [Overgrowth syndromes] | ||||||
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| MG30: Chronic pain | Fibromyalgia [Chronic pain] | ||||||
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| SD86: Dementia disorder | Dementia [Dementia disorder] | ||||||
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| XH0945: Squamous cell carcinoma | Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma] | ||||||
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| XH1ND9: Papillary carcinoma of thyroid | Papillary thyroid carcinoma [Papillary carcinoma of thyroid] | ||||||
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| XH1XF3: Osteosarcoma | Osteosarcoma [Osteosarcoma] | ||||||
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| XH3DV3: Adenoma | Adenoma [Adenoma] | ||||||
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| XH4546: Signet ring cell carcinoma | Signet ring cell colorectal cancer [Signet ring cell carcinoma] | ||||||
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| XH46F1: Clear cell renal cell carcinoma | Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma] | ||||||
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| XH4V32: Ductal carcinoma in situ | Ductal carcinoma in situ (DCIS) [Ductal carcinoma in situ] | ||||||
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| XH74S1: Adenocarcinoma | Small bowel adenocarcinoma [Adenocarcinoma] | ||||||
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| XH7PW5: Lymphocytic leukaemia | Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia] | ||||||
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| XH85Z0: Neuroblastoma | Neuroblastoma [Neuroblastoma] | ||||||
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| XH8844: Oligodendroglioma, anaplastic | Anaplastic oligodendrogliomas/oligoastrocytomas [Oligodendroglioma, anaplastic] | ||||||
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| XH8P29: Medulloblastoma | Primary medulloblastoma [Medulloblastoma] | ||||||
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| XH8P29: Medulloblastoma | Medulloblastoma [Medulloblastoma] | ||||||
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| XH94U0: Pituitary adenoma | Nonfunctioning pituitary adenomas [Pituitary adenoma] | ||||||
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| XN3DY: Helicobacter pylori | Helicobacter pylori infection [Helicobacter pylori] | ||||||
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| Protein(s) with this epigenetic modification | |||||||
|---|---|---|---|---|---|---|---|
| Protein Name: DNA cytosine methyltransferase | |||||||
| Detailed Information |
Pro Info
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[1] | |||||
| Description |
DNA cytosine methyltransferase(MTases) has been shown to translocate to the human cell nuclei and methylate the CPGI in the MMP2 gene promoter region.
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| Protein Name: Rv2966c | |||||||
| Detailed Information |
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[2] | |||||
| Description |
Rv2966c could hypermethylate the non-CpG dinucleotides at the host MMP2 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.
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