Target Information

Target General Infomation
Target ID
T98315
Former ID
TTDR01353
Target Name
mRNA of human acyl CoA cholesterol acyl-transferase-2
Gene Name
SOAT2
Synonyms
ACAT-2 (mRNA); Acyl-coenzyme A:cholesterol acyltransferase 2 (mRNA); Cholesterol acyltransferase 2 (mRNA); SOAT2 (mRNA); Sterol O-acyltransferase 2 (mRNA); SOAT2
Target Type
Research
Function
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoproteinsecretion from hepatocytes and intestinal mucosa.
BioChemical Class
Acyltransferase
Target Validation
T98315
UniProt ID
O75908
EC Number
EC 2.3.1.26
Sequence
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQL
RELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHF
RTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLA
PYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFL
MKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKN
FAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLH
CWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARG
VAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTM
LFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Inhibitor Oleic acid anilide Drug Info [528385]
PYRIPYROPENE A Drug Info [527340]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Steroid biosynthesis
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
References
Ref 527340Bioorg Med Chem Lett. 2005 Jan 17;15(2):385-8.Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors.
Ref 528385Bioorg Med Chem Lett. 2006 Nov 1;16(21):5580-3. Epub 2006 Aug 21.Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata.
Ref 549666US patent application no. 7,202,357, Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression.

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