Target Information

Target General Infomation
Target ID
T96816
Former ID
TTDR00360
Target Name
5-enopyruvyl shikimate 3-phosphate synthase
Gene Name
aroA
Synonyms
5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; Probable 3-phosphoshikimate 1-carboxyvinyltransferase; aroA
Target Type
Research
Disease Malaria [ICD10: B54]
Function
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
BioChemical Class
Alkyl aryl transferase
UniProt ID
Q9YEK9
EC Number
EC 2.5.1.19
Sequence
MVWLRAPDRVVVHPSTVEGRVEAPPSKSYTHRMLFLALLARGRSVVRRPLVSNDTLATLN
AVALLGGKPRLGRGVAEVEGGEVRGGAVVYAAGSGTTIRIAMGVAAHSAEATLLYGDESL
NRRPVHPLSEALRSMGARVCDTGGNPPVKVSGPLRRASVEVDAAISSQFATSLLIAGSRL
GEFELSAARLSSRGYVDITLESLSMFGVRVEREGYRLFRLRGTPKPVDAAVPGDYSSASF
MLAAGAIAGRVEVEGLRPVDPQPDRRIVELLRSMGARVRVEGGVVAVESTGPLEPVDVDL
DGSPDLAPVAAVLAAYARGVSRLRGLERLKYKESDRLSAIAWNLARLGVEARVRGGILEI
RGGGVEGGVARSWGDHRIAMAMAVAGLGARRPVAVEGFSRVPDSYPGFLEDLARLGARVE
AVKGGGV
Inhibitor Glyphosate Drug Info [535329], [536636]
References
Ref 535329The apicoplast as an antimalarial drug target. Drug Resist Updat. 2001 Jun;4(3):145-51.
Ref 536636Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97. Epub 2008 Feb 22.

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