Target Information

Target General Infomation
Target ID
T96014
Former ID
TTDR00662
Target Name
UDP-glucose 4-epimerase
Gene Name
GALE
Synonyms
Galactowaldenase; UDP-galactose4'-epimerase; UDP-galactose4-epimerase; GALE
Target Type
Research
Function
Catalyzes twodistinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
BioChemical Class
Racemases and epimerases
Target Validation
T96014
UniProt ID
Q14376
EC Number
EC 5.1.3.2
Sequence
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSV
EFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMK
AHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA
VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRD
YIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Inhibitor Glucose-Uridine-C1,5'-Diphosphate Drug Info [551393]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Phenyl-Uridine-5'-Diphosphate Drug Info [551393]
PSAMMAPLIN A Drug Info [528426]
Tetramethylammonium Ion Drug Info [551393]
Uridine Diphosphate Galactose Drug Info [551395]
Uridine-5'-Diphosphate Drug Info [551393]
Uridine-5'-Diphosphate-Mannose Drug Info [551393]
Uridine-Diphosphate-N-Acetylgalactosamine Drug Info [551393]
Uridine-Diphosphate-N-Acetylglucosamine Drug Info [551391]
Pathways
BioCyc Pathway D-galactose degradation V (Leloir pathway)
UDP-N-acetyl-D-galactosamine biosynthesis I
UDP-N-acetyl-D-galactosamine biosynthesis II
KEGG Pathway Galactose metabolism
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Fructose galactose metabolism
PathWhiz Pathway Nucleotide Sugars Metabolism
Galactose Metabolism
WikiPathways Metabolism of carbohydrates
References
Ref 528426Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7. Epub 2006 Sep 7.Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551395Crystal structure of beta1,4-galactosyltransferase complex with <span class="caps">UDP</span>-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.

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