Target Information

Target General Infomation
Target ID
T95139
Former ID
TTDR00070
Target Name
Cysteine protease
Target Type
Successful
Disease Trypanosomiasis [ICD9: 086.5-086; ICD10: B56-B57]
Target Validation
T95139
Drugs and Mode of Action
Drug(s) MELARSOPROL Drug Info Approved Trypanosomiasis [551871]
Inhibitor ALLICIN Drug Info [531093]
K-777 Drug Info [530398]
MELARSOPROL Drug Info [530346]
N-methyl-Pip-F-homoF-vinyl sulfonyl phenyl (N-methyl-Pip-F-hF-VS phi) Drug Info [536476]
S-benzyl phenylmethanesulfinothioate Drug Info [531093]
S-hexyl hexane-1-sulfinothioate Drug Info [531093]
S-isopentyl 3-methylbutane-1-sulfinothioate Drug Info [531093]
S-propyl propane-1-sulfinothioate Drug Info [531093]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 530346J Med Chem. 2009 Sep 24;52(18):5662-72.On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.
Ref 530398Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. Epub 2009 Sep 3.Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Ref 531093Bioorg Med Chem Lett. 2010 Sep 15;20(18):5541-3. Epub 2010 Aug 6.Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.
Ref 536476A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother. 2007 Nov;51(11):3932-9. Epub 2007 Aug 13.

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