Target Information

Target General Infomation
Target ID
T88430
Former ID
TTDR01370
Target Name
mRNA of A-Raf
Gene Name
ARAF
Synonyms
Proto-oncogene A-Raf (mRNA); Proto-oncogene A-Raf-1 (mRNA); Proto-oncogene Pks (mRNA); Serine/threonine-protein kinase A-Raf (mRNA); ARAF
Target Type
Clinical Trial
Disease Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation.
BioChemical Class
Kinase
UniProt ID
P10398
EC Number
EC 2.7.11.1
Sequence
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
Drugs and Mode of Action
Drug(s) RG7304 Drug Info Phase 1 Solid tumours [548874]
Inhibitor RG7304 Drug Info [551608]
Pathways
KEGG Pathway ErbB signaling pathway
FoxO signaling pathway
Vascular smooth muscle contraction
Natural killer cell mediated cytotoxicity
Long-term potentiation
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
PANTHER Pathway Angiogenesis
B cell activation
Integrin signalling pathway
Interleukin signaling pathway
PDGF signaling pathway
T cell activation
VEGF signaling pathway
Ras Pathway
CCKR signaling map ST
Reactome RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
WikiPathways ErbB Signaling Pathway
MAPK Cascade
Signaling Pathways in Glioblastoma
Integrated Breast Cancer Pathway
Integrin-mediated Cell Adhesion
References
Ref 548874Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029782)
Ref 549596US patent application no. 5,563,255, Antisense oligonucleotide modulation of raf gene expression.
Ref 549605US patent application no. 5,952,229, Antisense oligonucleotide modulation of raf gene expression.
Ref 551608Clinical pipeline report, company report or official report of Roche.

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