Target Information

Target General Infomation
Target ID
T85944
Former ID
TTDR00865
Target Name
UDP-3-O-[3-hydroxymyristoyl] n-acetylglucosamine deacetylase
Gene Name
lpxC
Synonyms
EnvA protein; LpxC; UDP-3-O-acyl-GlcNAc deacetylase; lpxC
Target Type
Research
Function
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
P47205
EC Number
EC 3.5.1.-
Sequence
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ
EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS
FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA
AAV
Inhibitor 3-(heptyloxy)benzoic acid Drug Info [551374]
BB-78484 Drug Info [535455]
BB-78485 Drug Info [535455]
Cacodylate Ion Drug Info [551393]
MYRISTIC ACID Drug Info [551374]
Palmitoleic Acid Drug Info [551393]
Tu-514 Drug Info [551393]
Pathways
KEGG Pathway Lipopolysaccharide biosynthesis
Metabolic pathways
References
Ref 535455Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrob Agents Chemother. 2002 Jun;46(6):1793-9.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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