Target Information

Target General Infomation
Target ID
T84581
Former ID
TTDS00276
Target Name
Thioredoxin reductase, cytoplasmic
Gene Name
TXNRD1
Synonyms
Cytosolic thioredoxin reductase; TR; TR1; Thioredoxin reductase; TrxR; TXNRD1
Target Type
Successful
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Malaria [ICD10: B54]
BioChemical Class
Oxidoreductases acting on a sulfur group of donors
Target Validation
T84581
UniProt ID
Q16881
EC Number
EC 1.8.1.9
Sequence
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
Drugs and Mode of Action
Drug(s) Fotemustine Drug Info Approved Cancer [551871]
Inhibitor 3-formyl-4-phenyl-1,2,5-oxadiazole 2-oxide Drug Info [530387]
4,6-dinitrobenzo[c][1,2,5]thiadiazole Drug Info [528012]
5,8-Dihydroxy-1,4-naphthoquinone Drug Info [536365]
Bis(2,4-dinitrophenyl)sulfane Drug Info [528012]
Flavin-Adenine Dinucleotide Drug Info [551393]
Fotemustine Drug Info [551393]
Spermidine Drug Info [551393]
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 528012Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. Epub 2006 Feb 3.Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.
Ref 530387J Med Chem. 2009 Oct 22;52(20):6474-83.Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
Ref 536365Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10. Epub 2007 Mar 6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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