Target Information

Target General Infomation
Target ID
T82723
Former ID
TTDR00292
Target Name
3-oxoacyl-[acyl-carrier-protein] synthase II
Gene Name
fabF
Synonyms
3-oxoacyl-[acyl-carrier-protein] synthase 2; Beta-ketoacyl-ACP synthase 2; Beta-ketoacyl-ACP synthase II; Beta-ketoacyl-acyl carrier protein synthase B; Condensing enzyme FabF; FabF; KAS 2; KAS II; KASB; fabF
Target Type
Research
Disease Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10: A00-B99]
Malaria [ICD10: B54]
Function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
BioChemical Class
Acyltransferase
UniProt ID
P0AAI5
EC Number
EC 2.3.1.41
Sequence
MSKRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCE
DIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHT
SLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAY
GDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLV
LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY
VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD
QAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI
Inhibitor Lauric Acid Drug Info [551393]
PLATENSIMYCIN Drug Info [551374]
Binder Thiolactomycin Drug Info [531635]
References
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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