Target Information

Target General Infomation
Target ID
T80175
Former ID
TTDR00955
Target Name
Dihydrolipoamide dehydrogenase, mitochondrial
Gene Name
LPD
Synonyms
Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; LipDH; Lipoamide dehydrogenase; LPD
Target Type
Research
Function
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.
BioChemical Class
Oxidoreductases acting on a sulfur group of donors
UniProt ID
P90597
EC Number
EC 1.8.1.4
Sequence
MFRRCAVKLNPYDVVVIGGGPGGYVASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKA
LLHATHVYHDAHANFARYGLMGGEGVTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYY
KGEGSFETAHSIRVNGLDGKQEMFETKKTIIATGSEPTELPFLPFDEKVVLSSTGALALP
RVPKTMVVIGGGVIGLELGSVWARLGAKVTVVEFAPRCAPTLDEDVTNALVGALAKNEKM
KFMTSTKVVGGTNNGDSVSLEVEGKNGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKN
ERGFVKIGDHFETSIPDVYAIGDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPA
VIYTMPEVASVGKSEEELKKEGVAYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRIL
GVHIVCTTAGELIGEACLAMEYGASSEDVGRTCHAHPTMSEALKEACMALVAKTINF
Inhibitor Flavin-Adenine Dinucleotide Drug Info [551393]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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