Target Information

Target General Infomation
Target ID
T73712
Former ID
TTDR00634
Target Name
Fatty acid-binding protein, liver
Gene Name
FABP1
Synonyms
14 kDa selenium-binding protein; 14-kDa fatty-acid binding protein; L-FABP; FABP1
Target Type
Discontinued
Disease Gout [ICD9: 274.00274.1274.8274.9; ICD10: M10]
Function
Binds free fatty acids andtheir coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
BioChemical Class
Calycin family
Target Validation
T73712
UniProt ID
P07148
Sequence
MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQ
NEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVF
KRISKRI
Drugs and Mode of Action
Drug(s) FENOFIBRIC ACID Drug Info Approved Cardiovascular disease [539727]
INDOPROFEN Drug Info Withdrawn from market Gout [551871]
Inhibitor 1-anilinonaphthalene-8-sulfonic acid Drug Info [529520]
FENOFIBRIC ACID Drug Info [529520]
INDOPROFEN Drug Info [529520]
OLEIC ACID Drug Info [529520]
Pathways
KEGG Pathway PPAR signaling pathway
Fat digestion and absorption
Reactome Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
WikiPathways Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Selenium Metabolism and Selenoproteins
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
References
Ref 539727(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2662).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 529520J Med Chem. 2008 Jul 10;51(13):3755-64. Epub 2008 Jun 6.Characterization of the drug binding specificity of rat liver fatty acid binding protein.

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