Target Information

Target General Infomation
Target ID
T70065
Former ID
TTDR00167
Target Name
Dihydroorotase
Gene Name
dho
Synonyms
DHOase; dho
Target Type
Research
BioChemical Class
Carbon-nitrogen hydrolase
UniProt ID
A9CSR1
EC Number
EC 3.5.2.3
Sequence
MKNYFYIPIADDMHCHLRQGDMLDFTVNSIRRGGCNRVLVMPNTHPIISTCSDAQKYLYQ
LKSRDDDIEYLMTLYLNKNTDENDILSNYYKCNLQGVKIYPSNVTTNSSDGITSLEPYYK
VFHALEKLNKSIHIHCEEPNINPLYAEEKYLPHIHDLAIKFPGLNIVLEHISSSESINVI
KEFRNVAGSITPHHLYLTIDDVVNMDIYDHAIDNTYIEKYIKNTYHYCKPLPKLLEDKIA
LQDVIKDDFPRVFLGSDSAPHYKVMKRKPYYKPGIYTQPFLINYVAHILNKFDALDKMEN
FTSKNASLFLNLAEKKKLAKYYICVEKHPFKLPREYNGVVPFLAGKTLDYDIHYVSKF
Inhibitor 5-amino orotate Drug Info [535811]
5-bromo orotate Drug Info [535811]
5-Fluoro orotate Drug Info [535811]
5-iodo orotate Drug Info [535811]
5-methyl orotate Drug Info [535811]
Dihydroorotic Acid Drug Info [551393]
Lysine Nz-Carboxylic Acid Drug Info [551393]
N-Carbamoyl-L-Aspartate Drug Info [551393]
Orotate Drug Info [535811]
References
Ref 535811Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase. Biochem Pharmacol. 1992 Mar 17;43(6):1295-301.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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