Target Information

Target General Infomation
Target ID
T60914
Former ID
TTDI03003
Target Name
5-HT3AB
Target Type
Research
Antagonist (S)-zacopride Drug Info [526116]
[3H]granisetron Drug Info [526116]
Agonist 1-phenylbiguanide Drug Info [526116]
2-methyl-5-HT Drug Info [534832]
meta-chlorphenylbiguanide Drug Info [526116]
Blocker (channel blocker) bilobalide Drug Info [531254]
Modulator (allosteric modulator) trichloroethanol Drug Info [527834]
References
Ref 526116Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors. Neuropharmacology. 2001 Aug;41(2):282-4.
Ref 527834Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res. 2005 Dec 14;142(2):146-50. Epub 2005 Oct 28.
Ref 531254Ginkgolide B and bilobalide block the pore of the 5-HT??eceptor at a location that overlaps the picrotoxin binding site. Neuropharmacology. 2011 Feb-Mar;60(2-3):488-95.
Ref 534832The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 1999 Jan 28;397(6717):359-63.

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