Target Information

Target General Infomation
Target ID
T59230
Former ID
TTDR00811
Target Name
Estradiol 17 beta-dehydrogenase 4
Gene Name
HSD17B4
Synonyms
17 beta-hydroxysteroid dehydrogenase type 4; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; HSD17B4
Target Type
Research
Function
Bifunctional enzymeacting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids.
BioChemical Class
Short-chain dehydrogenases reductases
UniProt ID
P51659
EC Number
EC 4.2.1.119
Sequence
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
MLSQKLQMILKDYAKL
Inhibitor 3r-Hydroxydecanoyl-Coa Drug Info [551391]
Nicotinamide-Adenine-Dinucleotide Drug Info [551393]
Pathways
BioCyc Pathway Fatty acid beta-oxidation (peroxisome)
KEGG Pathway Primary bile acid biosynthesis
Metabolic pathways
Peroxisome
PathWhiz Pathway Bile Acid Biosynthesis
WikiPathways Steroid Biosynthesis
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Prostate Cancer
Peroxisomal beta-oxidation of tetracosanoyl-CoA
Peroxisomal lipid metabolism
Bile acid and bile salt metabolism
References
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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