Target Information

Target General Infomation
Target ID
T54526
Former ID
TTDR01085
Target Name
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Gene Name
gpmI
Synonyms
BPG-independent PGAM; IPGM; Phosphoglycerate mutase; Phosphoglyceromutase; gpmI
Target Type
Research
Function
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
BioChemical Class
Intramolecular transferases
UniProt ID
P47669
EC Number
EC 5.4.2.1
Sequence
MHKKVLLAILDGYGISNAIYGNAVQNANTPMLDELINSYPCVLLDASGEAVGLPMGQIGN
SEVGHLNIGAGRVVYTGLSLINQHIKDRSFFANKAFLKTIEHVEKNHSKIHLIGLFSNGG
VHSHNEHLLALIELFSKHAKVVLHLFGDGRDVAPCSLKQDLEKLMIFLKNYPNVVIGTIG
GRYYGMDRDQRWDREMIAYKALLGVSKNKFNDPIGYIETQYQNQITDEFIYPAINANLNS
DQFALNNNDGVISFNFRPDRARQMSHLIFNSNYYNYQPELKRKENLFFVTMMNYEGIVPS
EFAFPPQTIKNSLGEVIANNNLKQLRIAETEKYAHVTFFFDGGFEVNLSNETKTLIPSLK
VATYDLAPEMSCKAITDALLEKLNNFDFTVLNFANPDMVGHTGNYQACIKALEALDVQIK
RIVDFCKANQITMFLTADHGNAEVMIDNNNNPVTKHTINPVPFVCTDKNVNFNQTGILAN
IAPTILEYLNLSKPKEMTAKSLLKNNN
Inhibitor 2-Phosphoglyceric Acid Drug Info [551393]
3-Phosphoglyceric Acid Drug Info [551393]
Clorsulon Drug Info [538042]
Pathways
KEGG Pathway Glycolysis / Gluconeogenesis
Glycine, serine and threonine metabolism
Methane metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Carbon metabolism
Biosynthesis of amino acids
References
Ref 538042Modes of action of anthelmintic drugs. Vet J. 1997 Jul;154(1):11-34.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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