Target Information

Target General Infomation
Target ID
T23145
Former ID
TTDS00419
Target Name
Cytochrome P450 11A1, mitochondrial
Gene Name
CYP11A1
Synonyms
CYP11A; CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; P450(scc); CYP11A1
Target Type
Successful
Disease Cushing's disease; Metastatic breast cancer [ICD9: 174, 175, 255.0; ICD10: C50, E24]
Function
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
BioChemical Class
Oxidoreductases acting on paired donors
UniProt ID
P05108
EC Number
EC 1.14.15.6
Sequence
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWL
NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPER
FLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVS
VLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQM
FHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRG
ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR
HQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIY
ALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINML
ENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ
Drugs and Mode of Action
Drug(s) Aminoglutethimide Drug Info Approved Cushing's disease; Metastatic breast cancer [535103], [542065]
Inhibitor 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione Drug Info [533478]
3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione Drug Info [533478]
Aminoglutethimide Drug Info [535103]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Pregnenolone biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Endogenous sterols
WikiPathways Prostaglandin Synthesis and Regulation
Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Glucocorticoid &amp
Mineralcorticoid Metabolism
Corticotropin-releasing hormone
Phase 1 - Functionalization of compounds
References
Ref 535103Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15.
Ref 542065(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7054).
Ref 533478J Med Chem. 1986 Aug;29(8):1362-9.Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones.
Ref 535103Breakdown of Th cell immune responses and steroidogenic CYP11A1 expression in CD4+ T cells in a murine model implanted with B16 melanoma. Cell Immunol. 2000 Nov 25;206(1):7-15.

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