Target Information

Target General Infomation
Target ID
T10091
Former ID
TTDR00221
Target Name
Rhodopsin
Gene Name
RHO
Synonyms
Opsin-2; RHO
Target Type
Research
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Function
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.
BioChemical Class
GPCR rhodopsin
Target Validation
T10091
UniProt ID
P08100
Sequence
MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP
EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES
ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAI
YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA
Inhibitor (Hydroxyethyloxy)Tri(Ethyloxy)Octane Drug Info [551393]
Alpha-D-Mannose Drug Info [551393]
B-2-Octylglucoside Drug Info [551393]
B-Nonylglucoside Drug Info [551374]
B-Octylglucoside Drug Info [551393]
Beta-D-Mannose Drug Info [551393]
Heptane-1,2,3-Triol Drug Info [551393]
Heptyl 1-Thiohexopyranoside Drug Info [551374]
Hexadecanal Drug Info [551391]
Lauryl Dimethylamine-N-Oxide Drug Info [551393]
N-Acetylmethionine Drug Info [551374]
NSC-88915 Drug Info [529643]
Palmitic Acid Drug Info [551393]
Phosphonoserine Drug Info [551393]
Phosphonothreonine Drug Info [551393]
Pathways
KEGG Pathway Phototransduction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Pathway Interaction Database Rods
Reactome The canonical retinoid cycle in rods (twilight vision)
Inactivation, recovery and regulation of the phototransduction cascade
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Visual phototransduction
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Integrin-mediated Cell Adhesion
References
Ref 529643J Med Chem. 2008 Sep 11;51(17):5297-303. Epub 2008 Aug 16.Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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