Target Information

Target General Infomation
Target ID
T09215
Former ID
TTDR00619
Target Name
Isocitrate lyase
Gene Name
icl
Synonyms
ICL; Isocitrase; Isocitratase; icl
Target Type
Research
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway (By similarity).
BioChemical Class
Carbon-carbon lyase
Target Validation
T09215
UniProt ID
P9WKK7
EC Number
EC 4.1.3.1
Sequence
MSVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLARRGAEVLWEQL
HDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDANLSGHTYPDQSLYPANSVPQV
VRRINNALQRADQIAKIEGDTSVENWLAPIVADGEAGFGGALNVYELQKALIAAGVAGSH
WEDQLASEKKCGHLGGKVLIPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSD
VDERDQPFITGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSEA
VKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLAGFHALNYSMFD
LAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGAGYFDRIATTVDPNSSTTALTG
STEEGQFH
Inhibitor 2,2',3-Tribromo-4,4',5,5'-tetrahydroxybibenzyl Drug Info [531190]
3-bromopyruvate Drug Info [535021]
3-nitropropionate Drug Info [535021]
5,5'-methylenebis(3,4-dibromobenzene-1,2-diol) Drug Info [531190]
Bis(2,3-dibromo-4,5-dihydroxyphenyl)ether Drug Info [531190]
Bis(3-bromo-4,5-dihydroxyphenyl)methanone Drug Info [531190]
Glyoxalate, Glyoxylate Drug Info [551393]
Halisulfate 1 Drug Info [528696]
Hydrohalisulfate 1 Drug Info [528696]
Pathways
KEGG Pathway Glyoxylate and dicarboxylate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Carbon metabolism
References
Ref 528696Bioorg Med Chem Lett. 2007 May 1;17(9):2483-6. Epub 2007 Feb 13.Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
Ref 531190Bioorg Med Chem Lett. 2010 Nov 15;20(22):6644-8. Epub 2010 Sep 21.Bromophenols as Candida albicans isocitrate lyase inhibitors.
Ref 535021Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000 Aug;7(8):663-8.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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