Target General Information
Target ID	T92609
Target Name	Alpha-1A adrenergic receptor
Synonyms	Alpha 1A-adrenoceptor; Alpha 1A-adrenoreceptor; Alpha adrenergic receptor 1c; Alpha-1C adrenergic receptor; ADRA1A
Target Type	Successful
Gene Name	ADRA1A
Biochemical Class	GPCR rhodopsin
UniProt ID	ADA1A_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Prostate cancer
Example drug	Dutasteride + tamsulosin			Phase 3	[521609], [1572592]
Tissue	Prostate
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.45 Z-score: 0.83 P-value: 2.24E-04
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Depression
Example drug	SDZ-NVI-085			Discontinued in Phase 1	[544963], [1572592]
Tissue	Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.03 Z-score: -0.25 P-value: 9.43E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 544963	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001726)
Ref 521609	ClinicalTrials.gov (NCT00090103) Benign Prostatic Hyperplasia Trial With Dutasteride And Tamsulosin Combination Treatment. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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