Target General Information
Target ID	T79062
Target Name	5-HT 7 receptor
Synonyms	5-HT-7; 5-HT-X; 5-HT7 receptor; 5HT7; Serotonin receptor; Serotonin receptor 7; HTR7
Target Type	Clinical Trial
Gene Name	HTR7
Biochemical Class	GPCR rhodopsin
UniProt ID	5HT7R_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Depression
Example drug	JNJ-18038683			Phase 2	[522172], [543133], [1572592]
Tissue	Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.08 Z-score: -0.32 P-value: 9.79E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Schizophrenia
Example drug	ATI-9242			Discontinued in Phase 2	[548733], [1572592]
Tissue	Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.03 Z-score: -0.11 P-value: 4.97E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Schizophrenia
Example drug	ATI-9242			Discontinued in Phase 2	[548733], [1572592]
Tissue	Superior temporal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -4.84E-04 Z-score: -3.66E-03 P-value: 3.78E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 548733	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028165)
Ref 543133	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8432).
Ref 522172	ClinicalTrials.gov (NCT00566202) A Safety and Effectiveness Study of JNJ-18038683 in Patients With Moderate to Severe Depression. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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