Target General Information
Target ID	T77913
Target Name	Histamine H1 receptor
Synonyms	H1 Histamine receptor; Histamine receptor 1; HRH1
Target Type	Successful
Gene Name	HRH1
Biochemical Class	GPCR rhodopsin
UniProt ID	HRH1_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Asthma
Example drug	Tripelennamine			Approved	[551871], [1572592]
Tissue	Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.30 Z-score: 0.55 P-value: 6.86E-09
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Depression
Example drug	Doxepin			Approved	[536306], [538737], [1572592]
Tissue	Pre-frontal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.17 Z-score: -0.25 P-value: 2.21E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Parkinson's disease
Example drug	Ethopropazine			Approved	[536923], [542192], [1572592]
Tissue	Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.13 Z-score: 0.43 P-value: 6.74E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Sensitive skin
Example drug	Vapitadine			Phase 2	[547977], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.06 Z-score: 0.17 P-value: 4.04E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 547977	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020866)
Ref 538737	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1225).
Ref 542192	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7181).
Ref 536306	Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39.
Ref 536923	Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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