Target General Information
Target ID	T55922
Target Name	S-adenosylmethioninedecarboxylase proenzyme
Synonyms	AdoMetDC; S-adenosylmethioninedecarboxylase; SamDC; AMD1
Target Type	Clinical Trial
Gene Name	AMD1
Biochemical Class	Carbon-carbon lyase
UniProt ID	DCAM_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Head and neck cancer
Example drug	MGBG			Terminated	[525957], [535793], [1572592]
Tissue	Head and neck tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.37 Z-score: 0.61 P-value: 4.41E-05
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 525957	Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8.
Ref 535793	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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