Target General Information
Target ID	T28265
Target Name	Alpha-1-antitrypsin
Synonyms	Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Alpha1-proteinase; PRO0684/PRO2209; SERPINA1
Target Type	Successful
Gene Name	SERPINA1
Biochemical Class	Serpin family
UniProt ID	A1AT_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Chronic obstructive pulmonary disease
Example drug	Alphagen			Phase 1	[536223], [1572592]
Tissue	Lung tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.08 Z-score: -0.10 P-value: 7.84E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Chronic obstructive pulmonary disease
Example drug	Alphagen			Phase 1	[536223], [1572592]
Tissue	Small airway epithelium
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.33 Z-score: 0.54 P-value: 1.32E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 536223	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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