Target General Information
Target ID	T22658
Target Name	Interleukin-8
Synonyms	Emoctakin; GCP-1; Granulocyte chemotacticprotein 1; IL-8; LYNAP; Lymphocyte-derived neutrophil-activating factor; MDNCF; MONAP; Monocyte derived neutrophil activating peptide; Monocyte-derived neutrophil chemotactic factor; NAF; NAP-1; Neutrophil-activating factor; Neutrophil-activating protein 1; Protein 3-10C; T-cell chemotactic factor; CXCL8
Target Type	Clinical Trial
Gene Name	CXCL8
Biochemical Class	Intercrine-alpha family
UniProt ID	IL8_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Melanoma
Example drug	ABX-IL8			Phase 2	[521511], [1572592]
Tissue	Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 2.09 Z-score: 3.08 P-value: 9.05E-17
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 521511	ClinicalTrials.gov (NCT00035828) A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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