Target General Information
Target ID	T22095
Target Name	Interleukin-17
Synonyms	CTLA-8; Cytotoxic T lymphocyte-associated antigen 8; IL-17; IL-17A; IL17A
Target Type	Successful
Gene Name	IL17B
Biochemical Class	Cytokine: interleukin
UniProt ID	IL17B_HUMAN||IL17C_HUMAN||IL17D_HUMAN||IL17F_HUMAN||IL17_HUMAN||IL25_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	ABT-122			Phase 2	[525076], [889413], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: -0.16 Z-score: -0.69 P-value: 2.91E-02
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 525076	ClinicalTrials.gov (NCT02349451) A Phase 2 Study to Investigate the Safety, Tolerability and Efficacy of ABT-122 in Subjects With Active Psoriatic Arthritis Who Have an Inadequate Response to Methotrexate. U.S. National Institutes of Health.
Ref 889413	ClinicalTrials.gov (NCT02433340) Phase 2, Multicenter, Open-Label Extension (OLE) Study With ABT-122 in Rheumatoid Arthritis Subjects Who Have Completed the Preceding M12-963 Study
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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