Target General Information
Target ID	T17852
Target Name	Phosphodiesterase 9
Synonyms	High affinity cGMPspecific 3',5'cyclic phosphodiesterase 9A; PDE9A
Target Type	Clinical Trial
Gene Name	PDE9A {ECO:0000312|HGNC:HGNC:8795}
Biochemical Class	Phosphoric diester hydrolases
UniProt ID	PDE9A_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Alzheimer's disease
Example drug	PF-4447943			Phase 2	[522709], [1572592]
Tissue	Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.07 Z-score: 0.36 P-value: 8.73E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref 522709	ClinicalTrials.gov (NCT00930059) A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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