Drug Information

Drug General Information
Drug ID
D0X8DU
Former ID
DIB013589
Drug Name
Clinprost
Synonyms
Arteon; Isocarbacyclin methyl ester; TEI-9090; TTC-909; Clinprost (liposomal), Taisho; Clinprost (liposomal), Teijin
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Preregistration [545407]
Company
Teijin Ltd
Formula
C22H36O4
Canonical SMILES
[C@H]12[C@@H]([C@@H](/C=C/[C@@H](O)CCCCC)[C@@H](C2)O)CC<br />(=C1)CCCCC(=O)OC
CAS Number
CAS 88931-51-5
PubChem Compound ID
6436040
Target and Pathway
Target(s) Prostacyclin receptor Target Info Modulator [534510]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signaling
References
Ref 545407Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003132)
Ref 534510Protective effect of a prostaglandin I2 analog, TEI-7165, on ischemic neuronal damage in gerbils. Brain Res. 1997 Sep 26;769(2):321-8.

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