Drug Information

Drug General Information
Drug ID
D0EZ9C
Former ID
DIB002518
Drug Name
CTLA-4-XTEN
Synonyms
Cytotoxic T-lymphocyte protein 4 modulator (XTEN, rheumatoid arthritis/transplant rejection), Amunix
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Investigative [543700]
Company
Amunix Inc
Target and Pathway
Target(s) Cytotoxic T-lymphocyte protein 4 Target Info Modulator [543700]
KEGG Pathway Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Autoimmune thyroid disease
Rheumatoid arthritis
Pathway Interaction Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Reactome CTLA4 inhibitory signaling
WikiPathways Vitamin D Receptor Pathway
T-Cell Receptor and Co-stimulatory Signaling
Allograft Rejection
Costimulation by the CD28 family
References
Ref 543700(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743).
Ref 543700(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2743).

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