Drug Information

Drug General Information
Drug ID
D0ER2C
Former ID
DIB010821
Drug Name
Triptoreline
Synonyms
Triptoreline (microsphere depot formulation, prostate cancer); Triptoreline (microsphere depot formulation, prostate cancer), GP Pharm; Triptoreline (one-month sustained release formulation, prostate cancer), GP Pharm; Triptoreline (three-month sustained release formulation, prostate cancer), GP Pharm
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 4 [522253]
Company
GP Pharm SA
Formula
C64H82N18O13
PubChem Compound ID
56840880
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Modulator [528589]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 522253ClinicalTrials.gov (NCT00633347) Use of Antagonist Versus Agonist GnRH in Oocyte Recipient Endometrium Preparation. U.S. National Institutes of Health.
Ref 528589Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44.

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