Drug Information

Drug General Information
Drug ID
D06FGJ
Former ID
DIB000195
Drug Name
Protexia
Synonyms
RBChE; PEG-rBChE; PEGylated butyrylcholinesterase (recombinant human, nerve agent exposure), PharmAthene
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1 [522424]
Company
Nexia Biotechnologies Inc
Target and Pathway
Target(s) Cholinesterase Target Info Modulator [527984]
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
WikiPathways Irinotecan Pathway
References
Ref 522424ClinicalTrials.gov (NCT00744146) First Time in Human Study of Protexia. U.S. National Institutes of Health.
Ref 527984In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5.

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