Drug Information

Drug General Information
Drug ID
D07GVM
Former ID
DIB006385
Drug Name
JNJ-42491293
Synonyms
JNJ-42491293; MGlu2 receptor PET ligand (psychiatric disease); MGlu2 receptor PET ligand (psychiatric disease), Johnson & Johnson
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Discontinued in Phase 1 [523495]
Company
Johnson & Johnson Pharmaceutical Research & Development LLC
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Binder [525408]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 523495ClinicalTrials.gov (NCT01359852) A Study of [11C]JNJ-42491293, a Possible PET Ligand for the mGlu2 Receptor, in Healthy Adult Volunteers. U.S. National Institutes of Health.
Ref 525408Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders. Nat Rev Drug Discov. 2014 Sep;13(9):692-708. doi: 10.1038/nrd4308.

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