Drug Information

Drug General Information
Drug ID
D0O0JP
Former ID
DIB000730
Drug Name
EMA-401
Synonyms
Neuropathic pain targeting small molecules (postherpetic neuralgia), Spinifex
Drug Type
Small molecular drug
Indication Postherpetic neuralgia [ICD9: 53.19; ICD10:B02.2, G44.847, G53.0] Phase 2 [525181], [543095]
Company
Spinifex pharmaceuticals
Formula
C32H29NO5
InChI
InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
InChIKey
GHBCIXGRCZIPNQ-MHZLTWQESA-N
PubChem Compound ID
9937291
PubChem Substance ID
77469282, 103210545, 103979536, 124759951, 226746902, 252166586
Target and Pathway
Target(s) Type-2 angiotensin II receptor Target Info Antagonist [551699]
KEGG Pathway Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Renin-angiotensin system
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 525181ClinicalTrials.gov (NCT02435199) Clinical Trial Designed to Determine the Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy. U.S. National Institutes of Health.
Ref 543095(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8374).
Ref 551699Clinical pipeline report, company report or official report of Spinifex.

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