Drug Information

Drug General Information
Drug ID
D0P6OS
Former ID
DIB014659
Drug Name
TT-235
Synonyms
[beta,beta-(3-Thiapentamethylene)-beta-sulfanylpropionic acid,D-Trp2,Pen6,Arg8]-oxytocin acetate
Indication Miscarriage [ICD10:O03] Discontinued in Phase 1 [546859]
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [527375], [551871]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546859Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010692)
Ref 527375In vivo activity of the potent oxytocin antagonist on uterine activity in the rat. In Vivo. 2004 Nov-Dec;18(6):763-6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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