Drug Information

Drug General Information
Drug ID
D08OJU
Former ID
DIB009432
Drug Name
SOU-001
Synonyms
AA-10020; DRP-001
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Discontinued in Phase 2 [547251]
Company
Arachnova Therapeutics Ltd
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Modulator [527154]
Alpha-1A adrenergic receptor Target Info Modulator [527154]
Alpha-1D adrenergic receptor Target Info Modulator [527154]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Endothelin Pathways
GPCRs, Other
References
Ref 547251Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014478)
Ref 527154Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004 Aug;3(8):673-83.

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