Drug Information

Drug General Information
Drug ID
D03FVR
Former ID
DIB012008
Drug Name
GSK-1827771
Synonyms
IL-1 antagonist (antibody, rheumatoid arthritis), GSK
Drug Type
Antibody
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 1 [522135]
Company
GlaxoSmithKline plc
Target and Pathway
Target(s) Interleukin-1 receptor, type II Target Info [550163]
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
Amoebiasis
HTLV-I infection
Transcriptional misregulation in cancer
NetPath Pathway IL1 Signaling Pathway
TNFalpha Signaling Pathway
Pathway Interaction Database IL1-mediated signaling events
Reactome Interleukin-1 signaling
WikiPathways MAPK Signaling Pathway
Interleukin-1 signaling
Apoptosis Modulation and Signaling
References
Ref 522135ClinicalTrials.gov (NCT00539760) A Phase I Rheumatoid Arthritis Study in Healthy Volunteers. U.S. National Institutes of Health.
Ref 550163WO patent application no. 2013,0077,63, Modulators of the nlrp3 inflammasome il-1ss pathway for the prevention and treatment of acne.

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