Drug Information

Drug General Information
Drug ID
D0H5KK
Former ID
DIB015249
Drug Name
Garnocestim
Synonyms
SB-251353
Indication Bone marrow transplantation [ICD9: 279.5, 996; ICD10:D89.8, T86] Discontinued in Phase 1 [546869]
Company
SmithKline Beecham plc
CAS Number
CAS 246861-96-1
Target and Pathway
Target(s) C-X-C chemokine receptor 4 Target Info Modulator [551900]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Axon guidance
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
IL4 Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Axon guidance mediated by Slit/Robo
Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database S1P3 pathway
CXCR4-mediated signaling events
Syndecan-4-mediated signaling events
HIF-1-alpha transcription factor network
Ephrin B reverse signaling
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Hematopoietic Stem Cell Differentiation
HIV Life Cycle
Cardiac Progenitor Differentiation
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546869Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010770)
Ref 551900CN patent application no. 101094684, With the combination of chemokine activation progenitor cells/stem cells.

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