Drug Information

Drug General Information
Drug ID
D03CGQ
Former ID
DIB004142
Drug Name
AG-013958
Synonyms
AG-13958
Indication Age related macular degeneration [ICD9: 362.5; ICD10:H35.3] Phase 1/2 [521610]
Company
Pfizer Inc
Target and Pathway
Target(s) VEGF receptor Target Info Inhibitor [544034]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
References
Ref 521610ClinicalTrials.gov (NCT00090532) A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration. U.S. National Institutes of Health.
Ref 544034Receptor Tyrosine Kinase Inhibitors AG013764 and AG013711 Reduce Choroidal Neovascularization in Rat Eye. Exp Eye Res. 2007 May; 84(5): 922-933.

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