Drug Information

Drug General Information
Drug ID
D0Y3RY
Former ID
DIB005376
Drug Name
R-1578
Synonyms
RG-1578; RG-1578); MGluR2 antagonist (depression), Roche; MGluR2 antagonist (Alzheimer's disease/depression), Roche
Indication Mood disorder [ICD10:F30-F39] Discontinued in Phase 2 [549263]
Company
Abiocode; Hoffmann-La Roche AG
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Antagonist [551608]
Metabotropic glutamate receptor 2 Target Info Antagonist [551608]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
References
Ref 549263Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034342)
Ref 551608Clinical pipeline report, company report or official report of Roche.

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