Drug Information

Drug General Information
Drug ID
D0L0LR
Former ID
DIB015375
Drug Name
UCL-67022
Synonyms
HDAC inhibitor (multiple myeloma), ST Barts/UCL
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Investigative [543662]
Company
University College London
Canonical SMILES
c1cccc(c1)NC(=O)C(CCCCCC(=O)NO)C(=O)Nc1ccccc1
Target and Pathway
Target(s) Histone deacetylase 6 Target Info Inhibitor [543662]
KEGG Pathway Alcoholism
Viral carcinogenesis
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary cilium
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell Cycle
References
Ref 543662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618).
Ref 543662(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2618).

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