Drug Information

Drug General Information
Drug ID
D0V9NE
Former ID
DNC002674
Drug Name
Tanaproget
Drug Type
Small molecular drug
Indication Estrogen deficiency [ICD10:E28.39] Investigative [542440]
Formula
C16H15N3OS
InChI
InChI=1S/C16H15N3OS/c1-16(2)12-8-10(4-6-13(12)18-15(21)20-16)14-7-5-11(9-17)19(14)3/h4-8H,1-3H3,(H,18,21)
InChIKey
PYVFWTPEBMRKSR-UHFFFAOYSA-N
PubChem Compound ID
4369524
PubChem Substance ID
7890671, 8025874, 9656061, 14849432, 35668696, 46393751, 46509047, 47207661, 50262950, 57356968, 103543239, 112947897, 134339410, 134339553, 135195438, 137009950, 137364372, 160854911, 160967765, 172821420, 178103988, 179150292, 185990464, 198936196, 210275263, 210280904, 226443727, 244300565
Target and Pathway
Target(s) Progesterone receptor Target Info Inhibitor [551374]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 542440(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7416).
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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