Drug Information

Drug General Information
Drug ID
D06NIT
Former ID
DIB012770
Drug Name
PF-4181366
Synonyms
PDE9A inhibitor (cognitive deficit), Pfizer
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Investigative [543409]
Company
Pfizer Inc
Canonical SMILES
c1(nc2c(c(=O)[nH]1)cnn2C1CCCC1)[C@@H]1CN(C[C@H]1C)Cc1cc<br />2nccnc2cc1
Target and Pathway
Target(s) Phosphodiesterase (PDE) 9 Target Info Inhibitor [543409]
KEGG Pathway Purine metabolism
Pathway Interaction Database Regulation of Androgen receptor activity
Reactome cGMP effects
References
Ref 543409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).
Ref 543409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).

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