Drug Information

Drug General Information
Drug ID
D00TBJ
Former ID
DIB014810
Drug Name
PF-271836
Synonyms
PF-271836; PF-2721374; PF-383965; PF-534422; PF-603059; UK-210587; UK-252820; UK-451402; Oxytocin antagonists (premature labor, prostatic hyperplasia, sexual dysfunction); Oxytocin antagonists (premature labor, prostatic hyperplasia, sexual dysfunction), Pfizer
Indication Female sexual dysfunction [ICD9: 302.7; ICD10:F52] Investigative [543799]
Company
Pfizer Inc
Canonical SMILES
c1(COCC)n(c(c2ccc(c(c2)C)OCC)nn1)c1ccc(nc1)OC
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [543799]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543799(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369).
Ref 543799(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 369).

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