Drug Information

Drug General Information
Drug ID
D0OW5Y
Former ID
DIB004439
Drug Name
NW-1772
Synonyms
Monoamine oxidase B inhibitors (neurodegenerative disease), Newron; MAO-B inhibitors (neurodegenerative disease), Newron
Indication Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] Investigative [543639]
Company
Newron Pharmaceuticals SpA
Canonical SMILES
S(=O)(=O)(O)C.c12oc(=O)cc(c1ccc(c2)OCc1cc(Cl)ccc1)CNC
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [543639]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compounds
References
Ref 543639(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).
Ref 543639(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2490).

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